Sidney Altman(1939–2022)
ChemistrySidney Altman is a recipient of the Nobel Prize in Chemistry (1989) from Canada. Their primary field is Chemistry. They were educated at Columbia University and Massachusetts Institute of Technology. They have been affiliated with Harvard University.
Canada
1
Major Awards
40
Publications
3,252
Citations
33
h-index
N/A
i10-index
81.3
Avg Citations/Paper
Awards & Recognition
1989
Most Cited Works
Top publications by citation count#1
Switchable targeting of solid tumors by BsCAR T cells
Proceedings of the National Academy of Sciences of the United States of America(2022)
25
citations
#2
Modified Oligonucleotides for Guiding RNA Cleavage Using Bacterial RNase P
Molecular Biology(2018)
5
citations
#3
Inactivation of expression of several genes in a variety of bacterial species by EGS technology
Proceedings of the National Academy of Sciences of the United States of America(2009)
43
citations
#4
Inactivation of gene expression using ribonuclease P and external guide sequences.
Methods in Enzymology(2000)
49
citations
#5
Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using disulfide-linked EDTA-Fe.
Journal of Molecular Biology(2000)
58
citations
#6
Rpp14 and Rpp29, two protein subunits of human ribonuclease P.
RNA: A publication of the RNA Society(1999)
57
citations
#7
Multiple binding modes of substrate to the catalytic RNA subunit of RNase P from Escherichia coli.
RNA: A publication of the RNA Society(1999)
26
citations
#8
The protein cofactor allows the sequence of an RNase P ribozyme to diversify by maintaining the catalytically active structure of the enzyme.
RNA: A publication of the RNA Society(1997)
48
citations
#9
Requirements for cleavage by a modified RNase P of a small model substrate.
Nucleic Acids Research(1996)
52
citations
#10
Processing of the precursor to the catalytic RNA subunit of RNase P from Escherichia coli.
RNA: A publication of the RNA Society(1995)
78
citations
Recent Publications
View all worksSwitchable targeting of solid tumors by BsCAR T cells
Proceedings of the National Academy of Sciences of the United States of America2022
25citations
Open AccessModified Oligonucleotides for Guiding RNA Cleavage Using Bacterial RNase P
Molecular Biology2018
5citations
Inactivation of expression of several genes in a variety of bacterial species by EGS technology
Proceedings of the National Academy of Sciences of the United States of America2009
43citations
Open AccessInactivation of gene expression using ribonuclease P and external guide sequences.
Methods in Enzymology2000
49citations
Mapping RNA-protein interactions in ribonuclease P from Escherichia coli using disulfide-linked EDTA-Fe.
Journal of Molecular Biology2000
58citations
Rpp14 and Rpp29, two protein subunits of human ribonuclease P.
RNA: A publication of the RNA Society1999
57citations
Open AccessMultiple binding modes of substrate to the catalytic RNA subunit of RNase P from Escherichia coli.
RNA: A publication of the RNA Society1999
26citations
Open AccessThe protein cofactor allows the sequence of an RNase P ribozyme to diversify by maintaining the catalytically active structure of the enzyme.
RNA: A publication of the RNA Society1997
48citations
Requirements for cleavage by a modified RNase P of a small model substrate.
Nucleic Acids Research1996
52citations
Open AccessProcessing of the precursor to the catalytic RNA subunit of RNase P from Escherichia coli.
RNA: A publication of the RNA Society1995
78citations
External Profiles
Education
Columbia University
Massachusetts Institute of Technology
University of Colorado Boulder
Doctoral Advisor
Benjamin C. Stark
Academy Memberships
National Academy of Sciences (US)American Academy of Arts and Sciences
Top Publications
Mesyl phosphoramidate backbone modified antisense oligonucleotides targeting miR-21 with enhanced in vivo therapeutic potency
Proceedings of the National Academy of Sciences202070 citations
Switchable targeting of solid tumors by BsCAR T cells
Proceedings of the National Academy of Sciences202229 citations
A kinase bioscavenger provides antibiotic resistance by extremely tight substrate binding
Science Advances202019 citations
Liquid drop of DNA libraries reveals total genome information
Proceedings of the National Academy of Sciences202014 citations
Related Laureates
Other winners of the same award(s)
KB
K. Barry Sharpless
Nobel Prize in Chemistry (2022)
FS
Frederick Sanger
Nobel Prize in Chemistry (1980)
OY
Omar Yaghi
Nobel Prize in Chemistry (2025)
GW
Greg Winter
Copley Medal (2025)
JM
John Michael Jumper
Fellow of the Royal Society (2025)
RR
Richard Robson
Nobel Prize in Chemistry (2025)
SK
Susumu Kitagawa
Nobel Prize in Chemistry (2025)
DH
Demis Hassabis
Nobel Prize in Chemistry (2024)
Data Sources
Profile data aggregated from Semantic Scholar, Wikidata, ORCID, and curated award records. Citation metrics may vary between sources.