K. Barry Sharpless(1941)
ChemistryKarl Barry Sharpless is an American stereochemist. He is a two-time Nobel laureate in chemistry, known for his work on stereoselective reactions and click chemistry.
United StatesScripps Research Institute
5
Major Awards
743
Publications
107,978
Citations
136
h-index
408
i10-index
145.3
Avg Citations/Paper
Awards & Recognition
Most Cited Works
Top publications by citation count#1
The Ionizing Zwitterionic Oxime Antidote Attenuates Gliosis in Mice Exposed to Sarin.
Chemico-Biological Interactions(2025)
0
citations
#2
579 Siglec-7/9 receptors suppress T cell immunity via trogocytosis and represent degradable targets for cancer immunotherapy
Regular and Young Investigator Award Abstracts(2024)
1
citations
#4
Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis
PLoS Neglected Tropical Diseases(2020)
17
citations
#5
Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase
Toxicology and Applied Pharmacology(2019)
12
citations
#6
Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.
Chemico-Biological Interactions(2013)
66
citations
#7
In vitro screening of acetylcholinesterase reactivating potency and oxime assisted organophosphate hydrolysis for a library of novel oxime reactivators synthesized by “click‐chemistry”.
The FASEB Journal(2008)
0
citations
#8
0
citations
#10
Click chemistry: an original approach for drug discovery
Acta Crystallographica Section A(2004)
0
citations
Recent Publications
View all worksThe Ionizing Zwitterionic Oxime Antidote Attenuates Gliosis in Mice Exposed to Sarin.
Chemico-Biological Interactions2025
0citations
579 Siglec-7/9 receptors suppress T cell immunity via trogocytosis and represent degradable targets for cancer immunotherapy
Regular and Young Investigator Award Abstracts2024
1citations
Open AccessClick chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis
PLoS Neglected Tropical Diseases2020
17citations
Open AccessCounteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase
Toxicology and Applied Pharmacology2019
12citations
Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.
Chemico-Biological Interactions2013
66citations
Open AccessClick chemistry: an original approach for drug discovery
Acta Crystallographica Section A2004
0citations
Open AccessCareer History
Professor
Scripps Research
La Jolla, US
Education
Stanford University
Ph.D.
Organic Chemistry
1968
Dartmouth College
B.A.
1963
Research Funding
NEW ASYMMETRIC PROCESSES FOR USE IN ORGANIC SYNTHESIS
National Institute of General Medical Sciences
New Metal Catalyzed Organic Transformations
Directorate for Mathematical & Physical Sciences
The Reactivity of Metal-Oxo and Metal-Imido Groups
Directorate for Mathematical & Physical Sciences
Drug Design Cycle targeting HIV Protease Drug Resistance
National Institute of General Medical Sciences
Practical Organic Oxidations in Water (TSE 99-A)
Directorate for Mathematical & Physical Sciences
Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry in Macromolecule Synthesis and Fabrication
Directorate for Mathematical & Physical Sciences
External Profiles
Career Path
Award progression over time
Apex Elite Prestigious
Co-winners
Shared the same award in the same year
CR
Carolyn R. Bertozzi
Nobel Prize in Chemistry (2022)
KB
Karl Barry Sharpless
Nobel Prize in Chemistry (2022)
MM
Morten Meldal
Nobel Prize in Chemistry (2022)
RN
Ryoji Noyori
Nobel Prize in Chemistry (2001)
RN
Ryōji Noyori
Nobel Prize in Chemistry (2001)
WS
William S. Knowles
Nobel Prize in Chemistry (2001)
WS
William Standish Knowles
Nobel Prize in Chemistry (2001)
HK
Henri Kagan
Wolf Prize in Chemistry (2001)
Education
Friends' Central School(high school diploma)
Stanford University(Doctor of Philosophy)
Dartmouth College(bachelor's degree)
Dartmouth College(Bachelor of Arts)
Harvard University
Doctoral Advisor
Eugene van Tamelen
Career Timeline
Massachusetts Institute of Technology?–present
Stanford University?–present
Scripps Research1990–present
Top Publications
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF<sub>4</sub>)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
Angewandte Chemie International Edition2019158 citations
SuFExable polymers with helical structures derived from thionyl tetrafluoride
Nature Chemistry2021150 citations
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery
Nature Chemistry2020130 citations
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
Angewandte Chemie International Edition2020123 citations
Sulfur fluoride exchange
Nature Reviews Methods Primers202396 citations
Books
Related Laureates
Other winners of the same award(s)
Omar Yaghi
Nobel Prize in Chemistry (2025)
David MacMillan
Wolf Prize in Chemistry (2021)
Benjamin List
Nobel Prize in Chemistry (2021)
Ahmed H. Zewail
Davy Medal (2011)
Robert H. Grubbs
Nobel Prize in Chemistry (2005)
John A. Pople
Copley Medal (2002)
Roald Hoffmann
Priestley Medal (1990)
John B. Goodenough
Nobel Prize in Chemistry (2019)
Data Sources
Profile data aggregated from OpenAlex, Semantic Scholar, Wikidata, ORCID, and curated award records. Citation metrics may vary between sources.