Charles Sawyers(1959)
Life SciencesCharles Sawyers is a recipient of the Breakthrough Prize in Life Sciences (2013) from United States. They have received 2 major awards in total. Their primary field is Life Sciences. They were educated at Princeton University and Johns Hopkins University. They have been affiliated with Memorial Sloan Kettering Cancer Center.
United StatesMemorial Sloan Kettering Cancer Center
2
Major Awards
624
Publications
99,266
Citations
130
h-index
281
i10-index
159.1
Avg Citations/Paper
Awards & Recognition
Most Cited Works
Top publications by citation count#1
Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers
Science Advances(2025)
9
citations
#2
1
citations
#3
PD09-09 ROLE OF TUMOR MICROENVIRONMENT DERIVED NRG1 IN ANDROGEN RESISTANCE: IMPLICATIONS FOR A NOVEL PROSTATE CANCER TREATMENT STRATEGY
Journal of Urology(2024)
1
citations
#4
ROLE OF TUMOR MICROENVIRONMENT DERIVED NRG1 IN ANDROGEN RESISTANCE: IMPLICATIONS FOR A NOVEL PROSTATE CANCER TREATMENT STRATEGY
Urologic oncology: Seminars and original investigations(2024)
0
citations
#5
2233MO CDC7 inhibition constrains lineage plasticity and prevents resistance and neuroendocrine transformation in the lung and prostate
Annals of Oncology(2023)
0
citations
#6
OA19.03 Exportin 1 Inhibition Constraints Lineage Plasticity and Histological Transformation through Downregulation of SOX2
Journal of Thoracic Oncology(2023)
0
citations
Recent Publications
View all worksUncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers
Science Advances2025
9citations
Open AccessROLE OF TUMOR MICROENVIRONMENT DERIVED NRG1 IN ANDROGEN RESISTANCE: IMPLICATIONS FOR A NOVEL PROSTATE CANCER TREATMENT STRATEGY
Urologic oncology: Seminars and original investigations2024
0citations
2233MO CDC7 inhibition constrains lineage plasticity and prevents resistance and neuroendocrine transformation in the lung and prostate
Annals of Oncology2023
0citations
Open AccessOA19.03 Exportin 1 Inhibition Constraints Lineage Plasticity and Histological Transformation through Downregulation of SOX2
Journal of Thoracic Oncology2023
0citations
Open AccessCareer History
Researcher
Memorial Sloan Kettering Cancer Center
New York, US
External Profiles
Career Path
Award progression over time
Apex Elite Prestigious
Co-winners
Shared the same award in the same year
SY
Shinya Yamanaka
Breakthrough Prize in Life Sciences (2013)
EL
Eric Lander
Breakthrough Prize in Life Sciences (2013)
BV
Bert Vogelstein
Breakthrough Prize in Life Sciences (2013)
RW
Robert Weinberg
Breakthrough Prize in Life Sciences (2013)
LC
Lewis Cantley
Breakthrough Prize in Life Sciences (2013)
TD
Titia de Lange
Breakthrough Prize in Life Sciences (2013)
NF
Napoleone Ferrara
Breakthrough Prize in Life Sciences (2013)
CB
Cornelia Bargmann
Breakthrough Prize in Life Sciences (2013)
DB
David Botstein
Breakthrough Prize in Life Sciences (2013)
HC
Hans Clevers
Breakthrough Prize in Life Sciences (2013)
BD
Brian Druker
Lasker Clinical Medical Research (2009)
Education
Princeton University
Johns Hopkins University
University of California, San Francisco
Montgomery Bell Academy
Career Timeline
Memorial Sloan Kettering Cancer Center?–present
University of California, Los Angeles?–present
Academy Memberships
National Academy of Sciences (US)American Academy of Arts and Sciences
Top Publications
Genomic correlates of clinical outcome in advanced prostate cancer
Proceedings of the National Academy of Sciences20191,200 citations
A rectal cancer organoid platform to study individual responses to chemoradiation
Nature Medicine2019479 citations
Lineage plasticity in cancer: a shared pathway of therapeutic resistance
Nature Reviews Clinical Oncology2020468 citations
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Science2022317 citations
Regenerative potential of prostate luminal cells revealed by single-cell analysis
Science2020276 citations
Related Laureates
Other winners of the same award(s)
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Carl June
Breakthrough Prize in Life Sciences (2024)
Michel Sadelain
Breakthrough Prize in Life Sciences (2024)
James P. Allison
Nobel Prize in Physiology or Medicine (2018)
John Michael Jumper
Fellow of the Royal Society (2025)
DL
David Liu
Breakthrough Prize in Life Sciences (2025)
Daniel J. Drucker
Breakthrough Prize in Life Sciences (2025)
JH
Joel Habener
Breakthrough Prize in Life Sciences (2025)
Andrew Singleton
Fellow of the Royal Society (2025)
Data Sources
Profile data aggregated from OpenAlex, Semantic Scholar, Wikidata, ORCID, and curated award records. Citation metrics may vary between sources.