Titia de Lange(1955)

Life Sciences

Titia de Lange is a recipient of the Gairdner International Award (2014) from Netherlands. They have received 2 major awards in total. Their primary field is Life Sciences. They were educated at University of Amsterdam and University of California, San Francisco. They have been affiliated with The Rockefeller University.

ORCIDWikipediaOpenAlex
NetherlandsRockefeller University
Gairdner International Award (2014)Breakthrough Prize in Life Sciences (2013)
WikipediaORCID
2
Major Awards
245
Publications
51,821
Citations
106
h-index
180
i10-index
211.5
Avg Citations/Paper

Awards & Recognition

2014
2013

Most Cited Works

Top publications by citation count
#1

Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen.

Molecules and Cells(2025)
4
citations
#2

How Shelterin Orchestrates the Replication and Protection of Telomeres.

Cold Spring Harbor Perspectives in Biology(2025)
6
citations
#3

Tetrameric TRF2 forms t-loop to protect telomeres from ATM signaling and cNHEJ

bioRxiv(2024)
3
citations
#4

DNA-PK controls Apollo’s access to leading-end telomeres

Nucleic Acids Research(2024)
15
citations
#5

ATR blocks telomerase from converting DNA breaks into telomeres

Science(2024)
15
citations
#6

CST–polymerase α-primase solves a second telomere end-replication problem

Nature(2024)
22
citations
#7

POT1 recruits and regulates CST-Polα/primase at human telomeres.

Cell(2024)
20
citations
#8

Replicative senescence is ATM driven, reversible, and accelerated by hyperactivation of ATM at normoxia

bioRxiv(2024)
4
citations
#9

Rate my Editor

Genes & Development(2023)
0
citations
#10

CST–Polymeraseα-primase solves a second telomere end-replication problem

bioRxiv(2023)
15
citations

Recent Publications

View all works

Attenuation of ATM signaling by ROS delays replicative senescence at physiological oxygen.

Molecules and Cells2025
4citations

How Shelterin Orchestrates the Replication and Protection of Telomeres.

Cold Spring Harbor Perspectives in Biology2025
6citations

Tetrameric TRF2 forms t-loop to protect telomeres from ATM signaling and cNHEJ

bioRxiv2024
3citations

DNA-PK controls Apollo’s access to leading-end telomeres

Nucleic Acids Research2024
15citations
Open Access

ATR blocks telomerase from converting DNA breaks into telomeres

Science2024
15citations

CST–polymerase α-primase solves a second telomere end-replication problem

Nature2024
22citations
Open Access

POT1 recruits and regulates CST-Polα/primase at human telomeres.

Cell2024
20citations
Open Access

Replicative senescence is ATM driven, reversible, and accelerated by hyperactivation of ATM at normoxia

bioRxiv2024
4citations
Open Access

Rate my Editor

Genes & Development2023
0citations
Open Access

CST–Polymeraseα-primase solves a second telomere end-replication problem

bioRxiv2023
15citations
Open Access

Career History

Researcher

Rockefeller University

New York, US

1990 — Present

Education

University of Amsterdam

PhD

1985

Research Funding

Genome Instability in Breast Cancer

The Breast Cancer Research Foundation Inc.

2024 — 2025

Genome Instability in Breast Cancer

The Breast Cancer Research Foundation Inc.

2021 — 2022

Genome Instability in Breast Cancer

The Breast Cancer Research Foundation Inc.

2023 — 2024

Genome Instability in Breast Cancer

The Breast Cancer Research Foundation Inc.

2022 — 2023

Genome Instability in Breast Cancer

The Breast Cancer Research Foundation Inc.

2018 — 2019

Genome Instability in Breast Cancer

The Breast Cancer Research Foundation Inc.

2020 — 2021

Genome Instability in Breast Cancer

The Breast Cancer Research Foundation Inc.

2019 — 2020

Genome Instability in Breast Cancer

The Breast Cancer Research Foundation Inc.

2017 — 2018

Tel2 as a potential target for cancer therapy

The Breast Cancer Research Foundation Inc.

2010 — 2018

Telomere-dysfunction induced tetraploidization - relevance to cancer

The Breast Cancer Research Foundation Inc.

2012 — 2018

External Profiles

ID
ORCID
0000-0002-9267-367X
OpenAlex
Publications & Citations
Wikidata
Structured Data
Wikipedia
Biography
Semantic Scholar
Publications & Citations

Career Path

Award progression over time

2013
Breakthrough Prize in Life SciencesRockefeller University
2014
Gairdner International AwardThe Rockefeller University
Apex Elite Prestigious

Co-winners

Shared the same award in the same year

JP
James P. Allison
Gairdner International Award (2014)
TH
Tasuku Honjo
Gairdner International Award (2014)
NF
Napoleone Ferrara
Gairdner International Award (2014)
MF
Marc Feldmann
Gairdner International Award (2014)
HF
Harold F. Dvorak
Gairdner International Award (2014)
RN
Ravinder N. Maini
Gairdner International Award (2014)
SY
Shinya Yamanaka
Breakthrough Prize in Life Sciences (2013)
EL
Eric Lander
Breakthrough Prize in Life Sciences (2013)
BV
Bert Vogelstein
Breakthrough Prize in Life Sciences (2013)
RW
Robert Weinberg
Breakthrough Prize in Life Sciences (2013)
LC
Lewis Cantley
Breakthrough Prize in Life Sciences (2013)
CB
Cornelia Bargmann
Breakthrough Prize in Life Sciences (2013)

Education

University of Amsterdam
University of California, San Francisco

Academy Memberships

National Academy of Sciences (US)American Academy of Arts and Sciences

Top Publications

Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs
Cell2020236 citations
APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis
Nature Genetics2020143 citations
TRF2 binds branched DNA to safeguard telomere integrity
Nature Structural & Molecular Biology201780 citations
53BP1–shieldin-dependent DSB processing in BRCA1-deficient cells requires CST–Polα–primase fill-in synthesis
Nature Cell Biology202262 citations
ATRX affects the repair of telomeric DSBs by promoting cohesion and a DAXX-dependent activity
PLOS Biology202061 citations

Related Laureates

Other winners of the same award(s)

Huda Zoghbi
Huda Zoghbi
Horwitz Prize (2022)
John Michael Jumper
John Michael Jumper
Fellow of the Royal Society (2025)
DL
David Liu
Breakthrough Prize in Life Sciences (2025)
Daniel J. Drucker
Daniel J. Drucker
Breakthrough Prize in Life Sciences (2025)
JH
Joel Habener
Breakthrough Prize in Life Sciences (2025)
Katalin Karikó
Katalin Karikó
Gruber Prize in Neuroscience (2024)
Demis Hassabis
Demis Hassabis
Nobel Prize in Chemistry (2024)
John M. Jumper
John M. Jumper
Nobel Prize in Chemistry (2024)

Data Sources

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