Robert J. Lefkowitz(1943)
ChemistryRobert Joseph Lefkowitz is an American physician and biochemist. He is best known for his discoveries that reveal the inner workings of an important family of G protein-coupled receptors, for which he was awarded the 2012 Nobel Prize for Chemistry with Brian Kobilka. He is currently an Investigator with the Howard Hughes Medical Institute as well as a James B.
United StatesHoward Hughes Medical Institute
3
Major Awards
856
Publications
146,386
Citations
213
h-index
688
i10-index
171
Avg Citations/Paper
Awards & Recognition
Most Cited Works
Top publications by citation count#1
Translating science to medicine: The case for physician-scientists
Science Translational Medicine(2022)
24
citations
#2
Saving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs.
New England Journal of Medicine(2019)
134
citations
#4
Inspiring the next generation of physician-scientists.
Journal of Clinical Investigation(2015)
7
citations
#7
Focus on the research journey. An interview with Robert J. Lefkowitz, MD, scientist, mentor, and recipient of the 2007 National Medal of Science by Elaine Musgrave.
Clinical and Translational Science(2009)
0
citations
#8
Science Translational Medicine Podcast: 7 October 2009
Science Translational Medicine(2009)
0
citations
#9
An Interview with Professor Robert J. Lefkowitz, M.D.
Assay and drug development technologies(2003)
0
citations
Recent Publications
View all worksTranslating science to medicine: The case for physician-scientists
Science Translational Medicine2022
24citations
Open AccessSaving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs.
New England Journal of Medicine2019
134citations
A Serendipitous Scientist.
Annual Review of Pharmacology and Toxicology2018
3citations
Inspiring the next generation of physician-scientists.
Journal of Clinical Investigation2015
7citations
Open Access0citations
A tale of two callings.
Journal of Clinical Investigation2011
3citations
Open AccessFocus on the research journey. An interview with Robert J. Lefkowitz, MD, scientist, mentor, and recipient of the 2007 National Medal of Science by Elaine Musgrave.
Clinical and Translational Science2009
0citations
Open AccessScience Translational Medicine Podcast: 7 October 2009
Science Translational Medicine2009
0citations
An Interview with Professor Robert J. Lefkowitz, M.D.
Assay and drug development technologies2003
0citations
0citations
Career History
James B. Duke Professor of Medicine
Duke University
Durham, US
Research Funding
Molecular Regulation of Cardiovascular 7 TM Receptors
National Heart Lung and Blood Institute
External Profiles
Career Path
Award progression over time
Apex Elite Prestigious
Co-winners
Shared the same award in the same year
BK
Brian K. Kobilka
Nobel Prize in Chemistry (2012)
EH
Elizabeth H. Blackburn
Massry Prize (2007)
CW
Carol W. Greider
Massry Prize (2007)
JW
Jack W. Szostak
Massry Prize (2007)
MB
Michael Berridge
Gairdner International Award (1988)
TR
Thomas R. Cech
Gairdner International Award (1988)
AE
Anthony Epstein
Gairdner International Award (1988)
YN
Yasutomi Nishizuka
Gairdner International Award (1988)
AA
Albert Aguayo
Gairdner International Award (1988)
Education
Columbia University
Duke University
Bronx High School of Science
Columbia University Vagelos College of Physicians and Surgeons
Doctoral Advisor
Top Publications
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR
Science2020228 citations
Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor
Science2020228 citations
Structure of an endosomal signaling GPCR–G protein–β-arrestin megacomplex
Nature Structural & Molecular Biology2019216 citations
Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9
Science Signaling2018206 citations
G Protein-Coupled Receptors: A Century of Research and Discovery
Circulation Research2024129 citations
Related Laureates
Other winners of the same award(s)
Frederick Sanger
Nobel Prize in Chemistry (1980)
Roger Y. Tsien
Nobel Prize in Chemistry (2008)
Avram Hershko
Nobel Prize in Chemistry (2004)
Kary B. Mullis
Nobel Prize in Chemistry (1993)
Paul Berg
Gairdner International Award (1983)
Greg Winter
Copley Medal (2025)
John Michael Jumper
Fellow of the Royal Society (2025)
Demis Hassabis
Nobel Prize in Chemistry (2024)
Data Sources
Profile data aggregated from OpenAlex, Semantic Scholar, Wikidata, ORCID, and curated award records. Citation metrics may vary between sources.