ZC
Zhijian Chen
Life SciencesZhijian Chen is a recipient of the Shaw Prize in Life Science (2024) from China. They have received 2 major awards in total. Their primary field is Life Sciences. They were educated at The Chinese University of Hong Kong and University of Würzburg. They have been affiliated with University of Rochester.
ChinaXiamen University
2
Major Awards
318
Publications
78,920
Citations
112
h-index
209
i10-index
248.2
Avg Citations/Paper
Awards & Recognition
Most Cited Works
Top publications by citation count#2
Innate immune sensing via the cGAS-STING pathway restricts extrachromosomal DNA–driven tumorigenesis
bioRxiv(2026)
0
citations
#4
KDM5 demethylases suppress R-loop-mediated ‘viral mimicry’ and DNA damage in breast cancer cells
bioRxiv(2025)
0
citations
#5
VDAC2 brake release: unleashing inflammation via IFNγ.
TIPS - Trends in Pharmacological Sciences(2025)
3
citations
#6
0
citations
#7
STING-induced noncanonical autophagy regulates endolysosomal homeostasis
Proceedings of the National Academy of Sciences of the United States of America(2025)
40
citations
#8
cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice
Proceedings of the National Academy of Sciences of the United States of America(2024)
7
citations
#9
The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion
Nature Communications(2024)
43
citations
#10
cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation
Science immunology(2024)
36
citations
Recent Publications
View all worksAdvancing the science of nucleic acids together
Molecular Therapy: Nucleic Acids2026
0citations
4citations
VDAC2 brake release: unleashing inflammation via IFNγ.
TIPS - Trends in Pharmacological Sciences2025
3citations
0citations
STING-induced noncanonical autophagy regulates endolysosomal homeostasis
Proceedings of the National Academy of Sciences of the United States of America2025
40citations
Open AccesscGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice
Proceedings of the National Academy of Sciences of the United States of America2024
7citations
Open AccessThe STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion
Nature Communications2024
43citations
Open AccesscGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation
Science immunology2024
36citations
Open AccessCareer History
Professor
University of Texas Southwestern Medical Center at Dallas
Dallas, US
Education
University at Buffalo - The State University of New York
Ph.D.
Biochemistry
1991
External Profiles
Career Path
Award progression over time
Apex Elite Prestigious
Co-winners
Shared the same award in the same year
Education
The Chinese University of Hong Kong
University of Würzburg(Doctor of Philosophy)
Chinese Academy of Sciences(Master of Science)
Peking University(Bachelor of Science)
Ulm University
Career Timeline
University of Rochester2006–2009
Tianjin University2009–present
Academy Memberships
National Academy of Sciences (US)
Top Publications
The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer
Journal of Experimental Medicine20181,104 citations
DNA-induced liquid phase condensation of cGAS activates innate immune signaling
Science2018956 citations
cGAS in action: Expanding roles in immunity and inflammation
Science2019954 citations
TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
Proceedings of the National Academy of Sciences2021489 citations
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
Science2021200 citations
Related Laureates
Other winners of the same award(s)
KK
Katalin Karikó
Gruber Prize in Neuroscience (2024)
Drew Weissman
Nobel Prize in Physiology or Medicine (2023)
Huda Zoghbi
Horwitz Prize (2022)
David Julius
Nobel Prize in Physiology or Medicine (2021)
FH
Franz-Ulrich Hartl
Wolf Prize in Medicine (2020)
.jpg?width=300)
Arthur Horwich
Wolf Prize in Medicine (2020)
Kazutoshi Mori
Shaw Prize in Life Science (2014)
%20-%20from%20Flicker%202194972175.jpg?width=300)
Peter Walter
Shaw Prize in Life Science (2014)
Data Sources
Profile data aggregated from OpenAlex, Semantic Scholar, Wikidata, ORCID, and curated award records. Citation metrics may vary between sources.