PC
Pieter Cullis(1946)
Life SciencesPieter Rutter Cullis is a Canadian physicist and biochemist known for his contributions to the field of lipid nanoparticles (LNP). Cullis and co-workers have been responsible for fundamental advances in the development of nanomedicines employing lipid nanoparticle (LNP) technology for cancer therapies, gene therapies and vaccines. This work has contributed to five drugs that have received clinical approval by the US Food and Drug Agency (FDA), the European Medicines Agency, and Health Canada.
4
Major Awards
412
Publications
54,081
Citations
108
h-index
317
i10-index
131.3
Avg Citations/Paper
Awards & Recognition
Most Cited Works
Top publications by citation count#1
Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency
Advances in Materials(2023)
166
citations
#3
63
citations
#4
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
Journal of Controlled Release(2023)
103
citations
#5
Lipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues
Molecular Therapy: Methods & Clinical Development(2023)
74
citations
#7
On the Influence of Nucleic Acid Backbone Modifications on Lipid Nanoparticle Morphology.
Langmuir(2022)
13
citations
#8
Synthesis and Characterization of Hybrid Lipid Nanoparticles Containing Gold Nanoparticles and a Weak Base Drug.
Langmuir(2022)
20
citations
#9
Development of a Child-Friendly Oral Drug Formulation Using Liposomal Multilamellar Vesicle Technology.
International journal of pharmaceutics(2022)
3
citations
#10
Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy.
Journal of Controlled Release(2022)
20
citations
Recent Publications
View all worksInduction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency
Advances in Materials2023
166citations
Open AccessOpportunities and challenges in mRNA-LNP vaccine design
Vaccine Insights2023
0citations
63citations
Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures
Journal of Controlled Release2023
103citations
Open AccessLipid nanoparticle mRNA systems containing high levels of sphingomyelin engender higher protein expression in hepatic and extra-hepatic tissues
Molecular Therapy: Methods & Clinical Development2023
74citations
Open Access29citations
On the Influence of Nucleic Acid Backbone Modifications on Lipid Nanoparticle Morphology.
Langmuir2022
13citations
Development of a Child-Friendly Oral Drug Formulation Using Liposomal Multilamellar Vesicle Technology.
International journal of pharmaceutics2022
3citations
Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy.
Journal of Controlled Release2022
20citations
Open AccessCareer History
Professor
University of British Columbia
Vancouver, CA
External Profiles
Career Path
Award progression over time
Apex Elite Prestigious
Co-winners
Shared the same award in the same year
Education
University of British Columbia
Top Publications
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
Nature Nanotechnology20191,443 citations
The current landscape of nucleic acid therapeutics
Nature Nanotechnology20211,191 citations
On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA
ACS Nano2018569 citations
Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics
Accounts of Chemical Research2019462 citations
On the role of helper lipids in lipid nanoparticle formulations of siRNA
Nanoscale2019359 citations
Related Laureates
Other winners of the same award(s)
HZ
Huda Zoghbi
Horwitz Prize (2022)
FZ
Feng Zhang
Gruber Prize in Genetics (2022)
David Julius
Nobel Prize in Physiology or Medicine (2021)
Emmanuelle Charpentier
Nobel Prize in Chemistry (2020)
Jennifer A. Doudna
Nobel Prize in Chemistry (2020)
FH
Franz-Ulrich Hartl
Wolf Prize in Medicine (2020)
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Arthur Horwich
Wolf Prize in Medicine (2020)
James P. Allison
Nobel Prize in Physiology or Medicine (2018)
Data Sources
Profile data aggregated from OpenAlex, Semantic Scholar, Wikidata, ORCID, and curated award records. Citation metrics may vary between sources.