SE
Stephen Elledge(1956)
Life SciencesStephen Joseph Elledge is an American geneticist. He is the current Gregor Mendel Professor of Genetics and of Medicine at the Department of Genetics of Harvard Medical School and in the Division of Genetics of the Brigham and Women's Hospital. His research is focused on the genetic and molecular mechanisms of eukaryotic response to DNA damage and is known as the discoverer of the DNA damage response (DDR).
United StatesHoward Hughes Medical Institute
3
Major Awards
538
Publications
122,258
Citations
172
h-index
378
i10-index
227.2
Avg Citations/Paper
Awards & Recognition
Most Cited Works
Top publications by citation count#1
Oppositely imprinted genes p57(Kip2) and igf2 interact in a mouse model for Beckwith-Wiedemann syndrome.
Genes & Development(1999)
167
citations
#2
DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America(1999)
145
citations
#4
Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells.
Genetics(1997)
73
citations
#7
Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae
Molecular and Cellular Biology(1997)
198
citations
#8
The Saccharomyces cerevisiae MEC1 gene, which encodes a homolog of the human ATM gene product, is required for G1 arrest following radiation treatment
Journal of Bacteriology(1996)
54
citations
#9
Selective maternal-allele loss in human lung cancers of the maternally expressed p57KIP2 gene at 11p15.5.
Oncogene(1996)
113
citations
#10
Finding prospective partners in the library: the two-hybrid system and phage display find a match.
TIBS -Trends in Biochemical Sciences. Regular ed(1995)
114
citations
Research Funding
Developing better cancer vaccines and the discovery of dark proteome epitopes in cancer cells.
American Cancer Society
External Profiles
Career Path
Award progression over time
Apex Elite Prestigious
Co-winners
Shared the same award in the same year
HZ
Huda Zoghbi
Breakthrough Prize in Life Sciences (2017)
YO
Yoshinori Ohsumi
Breakthrough Prize in Life Sciences (2017)
RN
Roel Nusse
Breakthrough Prize in Life Sciences (2017)
HF
Harry F. Noller
Breakthrough Prize in Life Sciences (2017)
GW
Greg Winter
Gairdner International Award (2013)
HJ
Harvey J. Alter
Gairdner International Award (2013)
MH
Michael Houghton
Gairdner International Award (2013)
DW
Daniel W. Bradley
Gairdner International Award (2013)
Education
Stanford University
Massachusetts Institute of Technology
University of Illinois Urbana–Champaign(bachelor's degree)
Career Timeline
Harvard Medical School?–present
Howard Hughes Medical Institute1993–present
Academy Memberships
National Academy of Sciences (US)
Top Publications
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Science20221,752 citations
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
Science2020576 citations
Origins of lymphatic and distant metastases in human colorectal cancer
Science2017434 citations
Related Laureates
Other winners of the same award(s)
DL
David Liu
Breakthrough Prize in Life Sciences (2025)
Victor Ambros
Nobel Prize in Physiology or Medicine (2024)
Gary Ruvkun
Nobel Prize in Physiology or Medicine (2024)
Svante Pääbo
Nobel Prize in Physiology or Medicine (2022)
Emmanuelle Charpentier
Nobel Prize in Chemistry (2020)
Jennifer A. Doudna
Nobel Prize in Chemistry (2020)
Michael Hall
Lasker Basic Medical Research (2017)
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Eric Lander
Breakthrough Prize in Life Sciences (2013)
Data Sources
Profile data aggregated from OpenAlex, Semantic Scholar, Wikidata, ORCID, and curated award records. Citation metrics may vary between sources.